In South Carolina, workers’ compensation claims have two critical deadlines: you must notify your employer of the injury within 90 days of the accident or discovery, or risk denial unless they had actual notice or were not prejudiced, and you must file a claim with the Workers’ Compensation Commission within two years of the injury or death in a fatal case. For occupational diseases, the two‑year period begins when you knew or should have known the condition was work‑related. Acting quickly strengthens evidence and improves your claim.