You must file a workers’ compensation claim with the South Carolina Workers’ Compensation Commission within two years of the date of your workplace injury or the date you discovered your occupational illness. For occupational diseases that develop over time, such as hearing loss, respiratory conditions, or repetitive motion injuries, the clock typically starts when you knew or should have known that your condition was work-related. Missing this deadline will permanently bar you from recovering benefits, so it is critical to act promptly. The 90-day reporting requirement to your employer is a separate and earlier deadline.